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Predominantly gastrointestinal nausea, diarrhea, vomiting, constipation, and decreased appetite all dose-dependent and most common after a dose or an escalation

Second-line therapies include lidocaine, capsaicin patches, and tramadol [164]

Plasma biochemicals, including lipoproteins, lipids, glycoproteins and metabolites were quantified using proton nuclear magnetic resonance spectroscopy (H-NMR)

At the end of 16 weeks, the animals were fasted overnight and then euthanized by exposure to isoflurane (Webster Veterinary Supply Inc., Devens, MA)

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