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In people with obesity or metabolic syndrome, expanded visceral adipose tissue becomes dysfunctional, characterized by adipocyte hypertrophy, chronic hypoxia, and increased immune cell infiltration (Anstee et al., 2013[3]

Nanoencapsulation allows the co-delivery of synergistic agents, such as GPX4 inhibitors (RSL3, FIN56), iron donors, and lipid peroxidation amplifiers, at reduced individual doses to circumvent toxicity thresholds and overcome resistance mechanisms [102, 103]

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Gastrointestinal Discomfort: Nausea, upset stomach, or mild diarrhea

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