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High glucose levels lead to the creation of advanced glycation end products (AGEs), which contribute to fibrotic tissue formation [28], and both AGEs and excess insulin can promote fibroblast proliferation and ECM production [29,30]

Epitalon's chromatin remodeling effect demonstrated in Khavinson's 2003 work on heterochromatin activation in aged cells removes structural barriers to gene expression that would otherwise limit GHK-Cu's transcriptional effects.11 Epitalon opens the chromatin

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In patients with baseline normal ammonia levels, the NIRS data of l-carnitine group (n = 31) at 8 weeks of treatment were significantly better than that of the control group (n = 25) (0.11 0.09 vs