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(B-F) After 24h in culture with either 250uM melatonin or vehicle control the concentrations of IL-5 (B), IL-13 (C) , IL-9 (D) IL-10 (E) , and IL-6 (F) was determined by LEGENDPlex assay

Cell Death Differ 27(10):27812796 Deas E, Cremades N, Angelova PR, Ludtmann MH, Yao Z, Chen S et al (2016) Alpha-synuclein oligomers interact with metal ions to induce oxidative stress and neuronal death in Parkinsons disease

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Athira Pharma (formerly M3 Biotechnology), the WSU spinout founded to commercialize Dihexa-derivative compounds, paid approximately $4 million in a False Claims Act settlement in January 2025 after a whistleblower exposed concealment of the research misconduct from federal grant agencies, and approximately $10 million in a separate class-action settlement to investors

Dose ranges below come from individual-compound research and community protocol structure