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Written By: Divyanjali Godage BPharm Reviewed By: Pharmacally Editorial Team The OASIS-4 phase 3 trial conducted by Novo Nordisk and published in the New England Journal of Medicine shows that once-daily oral semaglutide 25 mg produces clinically significant weight loss (mean weight loss 13.6% vs 2.2% with placebo at week 64)
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In addition to Kupffer cells, infiltrating monocyte-derived macrophages amplify the inflammatory milieu by secreting similar pro-inflammatory mediators and chemokines, contributing to disease progression from steatosis to steatohepatitis