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Addition of an amino group to the N-terminal of Dihexa also attenuates the protective response, suggesting that even small substitutions greatly alter the specificity of Dihexa for its target

Fernndez et al

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114,115 Neuronal activity, brain-derived neurotrophic factor (BDNF), or drugs that increase intracellular 3,5-cyclic AMP (cAMP) levels induce MeCP2 phosphorylation and dissociation of the nuclear receptor corepressor (NCOR) complex, thereby enabling transcription