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(No participant had diabetes

If you are currently taking medications, have existing health conditions, are pregnant or nursing, or are considering any major changes to your health regimen, consult your physician before starting any prescription treatment

Additionally, hypothyroidism often causes metabolic adaptations (reduced muscle mass, increased hunger signals, lower metabolic rate) that persist even after thyroid levels normalize

When both medications are present, they create competing signals in your metabolic pathways, potentially neutralizing or reducing the weight loss benefit you'd normally experience from semaglutide alone

a completed checklist is provided in the Supplementary Material (Supplementary Table S2) [13]