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It is also able to cross the blood-brain barrier (BBB) to reach the subarachnoid space of the leptomeninges, causing meningitis with or without septicemia (van Deuren et al., 2000)

Gender differences: A lifetime analysis of the economic burden of Alzheimer's disease

Risks and side effects are also well understood

Vascular damage is evident as a loss of tight junction proteins on endothelial cells, an increase of permeability and the detachment of astrocytes and pericytes (Figure 1) Dysregulation contributes to cerebrovascular accidents, generates inflammation, and is linked to neurodegenerative diseases, epilepsies, and neuroinflammatory disorders, including multiple sclerosis (Engelhardt and Ransohoff, 2011

Gastroenterology 131 , 15731583 (2006)