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Regarding participant characteristics, the majority of studies enrolled overweight or obese adults with type 2 diabetes, or those receiving glucose-lowering treatments such as metformin, SGLT2 inhibitors, DPP-4 inhibitors, or insulin

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Research indicates that AOD9604 can promote fat loss even in models lacking functional 3-adrenergic receptors, suggesting that additional mechanisms beyond classical adrenergic signaling are involved