Helix mimetics: Recent developments
Positive and negative aspects of l-carnitine supplementation need to be clarified, especially considering its metabolite trimethylamino- N -oxide, which may be associated with the etiology of some diseases [61]
The mechanism underlying carnitine's anti-aging effects involves multiple pathways: restoration of mitochondrial cardiolipin content and membrane integrity, enhancement of fatty acid oxidation to reduce lipotoxic stress, reduction of protein oxidation and carbonyl formation, improvement of calcium homeostasis and cellular signaling, and activation of stress resistance pathways that promote cellular resilience
Dramatic reduction of liver fat through synchronized effects on appetite, metabolism, and lipid oxidation 1
And finding the elements that are the same, and those that are unique for each of these groups, is going to be important to giving them the right support. Looking at GLP-1 use as a journey, adds Hannah Ackermann, vice president of marketing and nutrition affairs at prebiotic ingredient company COMET, will also likely require the formulation of new companion and maintenance products to support users at different points in their journey
