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Introduction Acute Kidney Injury (AKI) is referred as a transient decline of renal function, which confers the severe clinical syndrome associated with high mortality (Bellomo et al., 2012)

ROS accumulation is exacerbated by mitochondrial membrane disruption, loss of membrane potential, and impaired ATP synthesis (Figure 1

An increased liver weight of 110% at one year was not associated with liver tumorigenesis, whereas liver tumorigenicity was seen if the one-year liver weight was 150% of control values (Carmichael et al

doi:10.1038/nrd3362