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Starting body composition plays a major role, with individuals carrying higher body fat percentages often experiencing more dramatic absolute changes, while leaner individuals may see slower but steady improvements in stubborn fat areas
These changes appear to result from weight loss and improved insulin sensitivity rather than direct ovarian effects
doi: 10.1016/j.vetimm.2016.08.011 245 HassonDCWatanabe-ChaillandMRomick-RosendaleLKoterbaAMinerDSLahniPet al
Reduced caloric intake is one hypothesis
This may also imply that these drugs are most beneficial when used in conjunction with other interventions, such as lifestyle changes or other medications, he added
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