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This regimen (shown as a 50:50 dosage ratio) is more difficult to adjust because NPH has both a 2 hour delay, limited duration of action, and a time course that gives it prandial-like properties that can result in different levels of insulin stacking when another prandial insulin is given concomitantly (see Figure 14)

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Doyle SL, Donohoe CL, Lysaght J, Reynolds JV

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Rising prevalence of diabetes and obesity, advancement in drug delivery technologies, and growing focus on preventive healthcare and personalized medicine are major key factors driving the market revenue growth of the GLP-1 Receptor Agonist market