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B12 injections are typically prescribed for individuals with pernicious anaemia, malabsorption disorders, or confirmed dietary deficiencies

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However, we recognized in the CY 2025 OPPS/ASC proposed rule (89 FR 59201 through 59204) that there are rare instances in which cell and gene therapies appear on the same claim as a primary C-APC service and therefore, have their payment packaged with payment for the primary C-APC service

Some programs use separate injections, with semaglutide weekly and B12 either weekly or every two weeks

Key findings from SURMOUNT-1 include a mean weight loss of 15.0% at the 5mg dose, 19.5% at the 10mg dose, and 20.9% at the 15mg dose over 72 weeks