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Comment: A commenter requested that we remove the Multiple Procedure Payment Reduction (MPPR) assignment from CPT code 64596 (insertion of neurostimulator electrode array, peripheral nerve) and reassign it from Y to N status in ASC Addendum AA for CY 2026, stating that the current multi-procedure discount results in inequitable payment access since bilateral implantation or multiple nerve targeting requires separate StimRouter devices with individual incision and tunneling procedures

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In addition, several studies have shown co-overexpression of EpCAM and c-Met pathways and their significant interaction in developing resistance to currently targeted therapies in cancer tissues

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