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This, in turn, triggers the HIF1A (hypoxia inducible factor 1 subunit alpha)-dependent Warburg effect and AIM2 (absent in melanoma 2)-dependent inflammasome activation, contributing to Kras G12D -induced pancreatic tumorigenesis [212]

The first reported observation that GTPases influence eryptosis was by Attanzio et al., who showed that NSC23766, a specific inhibitor of Rac1 GTPase, was able to ameliorate oxysterol-induced eryptosis [180]

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Prioritizing self-care, staying hydrated, and focusing on nutrient-rich foods are essential steps in managing these symptoms

Pregnant individuals, those with a personal history of pancreatitis triggered by GLP-1 use, and patients on incompatible medications should discuss alternatives with their provider