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The amino acid transporter SLC1A3 has an important role in maintaining Asp concentrations inside tumor cells and antagonizing the therapeutic effects of ASNase

Second, although we included recent human randomized controlled trials (e.g., SYNERGIC, DO-HEALTH, PONDER), the findings are mixed

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Importantly, there was no sex bias in mice receiving no treatment, saline or a therapeutic dose of the obesity drugs tesofensine or setmelanotide (Fig