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BBB disruption also enhances - and -secretase activity, promoting increased A production [157]

Persons taking most antibiotics, methotrexate and pyrimethamine invalidate folic acid and Vitamin B12 diagnostic blood assays

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However, if extremely high doses are given for a long time, pyridoxine can cause nerve damage leading to numbness or tingling in the hands and feet (peripheral neuropathy)

However, it's essential to consult with a healthcare professional, especially if you have underlying health conditions or are pregnant