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The first 4 to 8 weeks produce modest weight loss, primarily because the starting doses are sub-therapeutic for weight management
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Specifically, the ROS scavenger butylated hydroxyanisole delayed TNF-induced necroptosis but had no effect on necroptosis induced by direct RIPK3 oligomerization, suggesting that ROS may facilitate upstream signaling events rather than serve as an obligate execution mechanism 80
PMID 1632422
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