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Originally, GLP therapies were prescribed to help people with type 2 diabetes: Improve insulin secretion Reduce glucagon release (which raises blood sugar) Slow gastric emptying Stabilize post-meal glucose spikes These effects made GLPs incredibly effective for glycemic control

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Based on these differences, hepatocytes are categorized into three zones: periportal hepatocytes (Zone 1), midlobular hepatocytes (Zone 2), and pericentral venous hepatocytes (Zone 3)

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