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Choose tirzepatide when research focuses on GLP-1 and GIP receptor co-activation, dual incretin effects on adipose tissue biology, or when the research question involves GIP receptor pharmacology specifically

Common gastrointestinal side effects include: Nausea the most prevalent side effect, typically most pronounced during dose initiation and escalation, often improving with continued use Diarrhea can range from mild to moderate

15,29 Lifestyle modifications including physical activity, dietary changes, and weight loss are recommended as first-line therapy

Litchman, G., Nair, P

Commercial / Employer Group & marketplace plans Cigna commercial and employer-sponsored plans: Mounjaro is a non-preferred specialty drug at Tier 4/5 via Express Scripts (Evernorth), with prior authorization (confirmed T2D diagnosis, A1c 6.5% or higher, step therapy)