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O-GlcNAc levels can be increased by either glucosamine supplementation, which stimulates the hexosamine biosynthetic pathway, or pharmacological enzyme inhibition (e.g., inhibition of OGA) [61]

Injectable semaglutide is generally more effective for weight loss and controlling blood sugar, especially for non-diabetic individuals aiming for significant weight reduction

In the current study, Bartelt and colleagues compared outcomes among 7,773 patients who were prescribed phentermine approved by the FDA for weight management in 1959 after discontinuing a GLP-1 receptor agonist with 34,668 patients who were not prescribed phentermine after GLP-1 discontinuation