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Some studies have reported a benefit in elite endurance athletes with a high energy intake and expenditure

After 2-4 weeks of good tolerance, the dose increases to 1-1.5 mg daily

This underdiagnosis can lead, besides death in 20% when it is not appropriately treated, to Korsakoffs syndrome, a severe dysfunction often following untreated Wernickes encephalopathy, that does not remit even with thiamine treatment and is associated with chronic alcohol abuse and chronic thiamine deficiency (40, 42)

ETFDH mutation involves excessive apoptosis and neurite outgrowth defect via Bcl2 pathway

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