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The medication influences brain regions involved in emotional regulation

In breast cancer cells, AGR2 expression decreases the degradation of HIF-1 and increases MDR1 transcription, thus decreasing epirubicin uptake and promoting doxorubicin ( DOX ) resistance in breast cancer cells 42

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The choice should be individualized based on the primary indication (type 2 diabetes versus obesity), efficacy, side effect profile, dosing convenience, cost, and insurance coverage

"Clinical Practice Guideline for the Pharmacological Treatment of Chronic Insomnia in Adults." Journal of Clinical Sleep Medicine