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Ma A, Malynn BA (2012) A20: linking a complex regulator of ubiquitylation to immunity and human disease

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This interaction inhibits Keap1-mediated ubiquitination and degradation of NRF2, resulting in the upregulation of antioxidant genes and contributing to chemotherapy resistance in NSCLC [100]

When your body is under this kind of pressure, the rate at which you use antioxidants can outpace the rate at which you produce them