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88 found that the activated PPAR could induce the expression of its target gene uncoupling protein 2 (UCP2) and increase the activity of fatty acid -oxidation-related enzymes and peroxidase in mitochondria

Combined with regulated nutrition based on caloric intakes and physical workouts, it helps to lose fat

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These effects are mediated through several mechanisms: DPP-4 modulates inflammation in adipose tissue, a major site of vitamin D accumulation and action [22]

The restoration of GSK3-Drp1 signalling by Semaglutide was abolished in the presence of GLP-1R siRNA (Fig