The crude product was purified by a silica gel column chromatography using hexane and dichloromethane mixture (10:1 v/v) as eluent and obtained as yellow powder in 74% yield
-cell apoptosis is mediated by a series of cascade mechanisms of the cysteine protease family, and current studies on hyperglycemia-induced -cell apoptosis have focused on the balance between the pro-apoptotic Bcl-2 proteins (Bad, Bid, Bik, and Bax) and the anti-apoptotic Bcl family (Bcl-2 and Bcl-xl) (Tomita, 2016), and apoptosis occurs only when the concentration of the pro-apoptotic protein Bcl-2 on the mitochondrial membrane of the intrinsic pathway exceeds the concentration of the anti-apoptotic protein
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Demographic Data Across the 62 studies, there were a total of 66,232 patients (34,941 male/32,291 female) with a mean age of 58.3 years (14.4 to 68.0), mean duration of diabetes of 9.5 years (1.5 to 21.6), mean body mass index (BMI) of 32.6 kg/m 2 (24.4 to 46.2), and mean followup of 43.5 weeks (1 week to 198 weeks)
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