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Protein oxidation is another critical mechanism where free radicals modify amino acid side chains, form protein-protein cross-links, and fragment peptide chains

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Bile production and secretion The liver synthesizes and stores glycogen, which is a way to keep a glucose reserve for the "long term." Glycogen storage In addition to its roles in glucose storage and producing bile for fat metabolism, the liver also helps produce and break down amino acids as well as synthesize cholesterol

Piteau S, Olver A, Kim SJ et al (2007) Reversal of islet GIP receptor down-regulation and resistance to GIP by reducing hyperglycemia in the Zucker rat