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Introduction Carnosine is a histidine-containing dipeptide formed by beta-alanine (BA) and L-histidine that is abundant in human skeletal muscle ( + ) buffering ( + accumulation and can be improved by increasing buffering capacity ( Beta-alanine is a non-proteogenic amino acid and the limiting factor for carnosine formation in the skeletal muscle ( Muscle Carnosine Metabolism Carnosine homeostasis is dependent on its synthesis from, and degradation to, its constituent amino acids
More randomized clinical trials are needed to determine benefits of supplement use in women with PCOS
The rate of nausea in the latest trial for high-dose patients was 36.4%, while 23.1% experienced vomiting, compared with 8.4% and 3.8%, respectively, for the placebo group
(The drug is not approved for people under 18)
doi: 10.1056/NEJMoa055222 65
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