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doi: 10.1186/s13229-021-00447-5 11 ChangYWJangJYKimYHKimJWShimJJ

Coupled with earlier studies in human mammosphere cultures or mammary epithelial cell lines in which sulforaphane induces Nrf2 target genes 76 and diminishes the formation of estrogen-DNA adducts 29 , future clinical trials to address the protective function of broccoli sprout preparation against breast cancer risk is plausible

In gastric cancer (GC) samples Uc.416+A is highly expressed compared to non-cancer gastric mucosa, inversely with the expression of its putative target IGFBP-6 which is low in GC [74]

99 Once in the nucleus, it can activate various transcription factors such as hypoxia-inducible factor 1 alpha (HIF-1), histone H3, NRF2, and STAT3, influencing the activation of downstream target genes

Visualization of the bound antibodies was carried out by adding 200 L of mixed substrate solution and incubating the slides for 510 min at room temperature