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Included patients were those 18 years of age with a body-mass index (BMI) 27 kg/m 2 , HbA 1c of 7-10%, and a diagnosis of type 2 diabetes at least 180 days before screening

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Patients on GLP-1 medications losing more than 2 pounds weekly often benefit most because rapid weight loss increases hepatic lipid flux and oxidative stress simultaneously

We found this paradox to be explained by GLP-1 delaying gastric emptying and the rate of carbohydrate absorption after a meal, biological actions that dominant direct effects on insulin secretion at the B-cell, both in both normal-weight individuals and in non-diabetic individuals with obesity [6, 10] (Fig