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106 , e11e19 (2021)

Though CRISPR-guided base editing has made in situ DNA editing at the individual base level routine, 25 it and other CRISPR-based genome editing tools are typically used for making precise edits at the primary sequence level rather than for perturbation of DNA macrostructure and physical properties

Most human trials used about 12 grams per day, often split into two doses and continued for at least 812 weeks

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