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The substitution at position 2 is the functionally important one: it blocks cleavage by dipeptidyl peptidase-4, the protease that degrades native GRF within minutes

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Moreover, the optimal dose and formulation of melatonin for older adults require clarification sustained-release melatonin might better mimic the natural profile and sustain sleep through the night, for instance (Thanawala et al., 2024)