It is important to recognise that pharmaceutical GLP-1 agonists are not cosmetic weight-loss drugs but prescription medications for specific medical conditions
-Syn oligomers cause massive degeneration and loss of nigrostriatal dopaminergic neurons, in turn inducing PD through multiple mechanisms, involving mitochondrial dysfunction, endoplasmic reticulum stress, proteasomal influences, neuroglial cellular and inflammatory responses, membrane damage, synaptic dysfunction, autophagy and lysosomal dysfunction (Bengoa-Vergniory et al., 2017)
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(2002) Endogenous IL-10 inhibits APC stimulation of T lymphocyte responses to luminal bacteria [abstract]