The 5-point threshold represents a pragmatic and clinically meaningful choice, but future research should continue to refine our understanding of how best to measure and analyze disease progression in PD using TTE endpoints and explore the statistical properties of TTE analysis in more depth, comparing different modeling approaches and censoring mechanisms
Dosing: Both medications come as pre-filled injection pens
(T2) 15 min after administration of the smoked/inhaled dose
The reported results are promising: Over 80% relative bioavailability Around 160 higher bioavailability vs oral tablets Sustained drug levels for ~1 week (once-weekly dosing potential) Additionally, the microneedle patches are stable at room temperature, eliminating the need for cold storage, unlike semaglutide injections
It is also important to realize that exercise comes with additional health and longevity benefits (additional healthy years, significantly reduced risk of many chronic diseases, improved mental health, etc.)