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Patients with pre-existing gastroesophageal reflux disease (GERD), hiatal hernia, or obesity may be more susceptible

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Across different modalitiesincluding caloric restriction, exercise-based interventions, pharmacological agents, and bariatric surgeryweight reduction has been shown to result in bone loss, reduced BMD, and compromised bone quality

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Diarrhea usually starts to occur within the first 2 weeks after beginning Linzess treatment