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Similarly, recruitment of participants with severe hepatic impairment into the hepatic impairment study was challenging and, despite a third study site being added and the recruitment period being prolonged, it was not possible to complete recruitment of seven participants into the severe hepatic impairment group

In fibroblast models, researchers observed that GHK-Cu is associated with increased collagen type I and III synthesis, fibronectin production, and glycosaminoglycan deposition