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Effects of early rolipram treatment on histopathological outcome after controlled cortical impact injury in mice

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Although AD and VaD share common vascular risk factors, the contribution of small artery disease to VaD pathogenesis may be greater than that of AD [120].In fact, studies have found that neuropathic changes can be evident 20 years before the onset of dementia and that there is a substantial neuronal loss in the MCI stage, which is considered a transitional state before the onset of dementia [121]

PLoS One 14 , e0222947 (2019)