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POMC neurons and AgRP neurons in the arcuate extend dendrites that physically project into the median eminence to sample circulating hormones, glucose, and now, evidently, large peptide drug conjugates

With metabolic stress, leukocyteendothelial interactions become more adhesive and pro-inflammatory, contributing to endothelial dysfunction, vascular stiffness, and atherosclerotic progression

Given that several reviews have recently been written on the topics of microbial production of bile acids and mechanisms of their physiological functions (Liu et al., 2022a

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hepatology 75, S67S81