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Overall, these findings suggest that caffeine and paraxanthine hold therapeutic potential for improving cognitive function, particularly in younger individuals, by enhancing neuromodulation and reducing -amyloid accumulation

The assay was performed by monitoring the rate of NADPH consumption, measured as the decrease in optical density at 340 nm (OD 340nm ) over a 5-min period using a BioTek microplate reader

Reduced secretion of gastric acid and pepsin, from the use of H 2 blocker or proton-pump inhibitor (PPI) drugs, can reduce the absorption of protein-bound (dietary) vitamin B 12 , although not of supplemental vitamin B 12

based on efficacy and convenience

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