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los glucosricos: Inhibidor de SGLT2 y duales y la ms antigua y conocida Metformina, aunque esta ltima no ha demostrado claramente mejorar el control metablico de adolescentes con DM1, sin embargo logra disminucin del peso y de la dosis de Insulina, por lo que puede ser de utilidad en algunos casos

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It leads to changes in the structure of skin matrix proteins, such as collagen and elastin, and consequently, to loss of skin elasticity and firmness, the formation of wrinkles, and pigmentation disorders (116118)

Studies show significant weight regain after discontinuing either medication, typically recovering 50-70% of lost weight within 12 months

Xenobiotica (2013) 43(5):43242