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Collectively, these findings emphasize the central role of the VDR signaling axis in constraining aberrant melanocyte proliferation, with its progressive dysfunction potentially serving as a key determinant in the malignant transformation of benign nevi to melanoma
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2.5 Cell cycle assay USCs were seeded at a density of 1 10 4 cells/cm 2 and incubated under normoxic (21% O 2 ) or hypoxic (3% O 2 ) conditions for a duration of 3 and 5 days, with four replicates in each experimental group
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