retatrutide phase 2 trial type 2 diabetes results 2024 Efficacy and safety of retatrutide, a GIP, GLP-1, and glucagon receptor agonist, in people with and inadequate glycaemic control with diet and exercise (TRANSCEND-T2D-1): a double-blind, randomised, 3 The Effect of Retatrutide on

Hamasaki H

10.1016/s0140-6736(87)91194-9 49 KuH.ChenW.SuM

Initial results indicate that when comparing tirzepatide vs retatrutide, Retatrutide may lead to more substantial reductions in body mass, improving its efficacy in addressing obesity

Last reviewed: July 21, 2026 Last updated: July 21, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Semaglutide (Wegovy, Ozempic) Half-life: ~7 days Dosing: Once weekly subcutaneous injection Profile: Provides steady appetite suppression and glycemic control