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GLP-1 receptor agonistssuch as semaglutide (Wegovy, Ozempic) and tirzepatide (Mounjaro, Zepbound)work by mimicking hormones that regulate blood sugar, appetite, and digestion

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"We thought, if you have a problem with this enzyme, there's going to be multiple aspects of your biology that are not working properly." Previous research had already shown that PAM variants occur more often in people with diabetes

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These changes can disrupt the adaptive regulation of oxygenation in the retinal blood vessels, inhibit angiogenesis, and lead to further deterioration of the already compromised vascular endothelium in hyperglycemic conditions, potentially accelerating the progression of existing diabetic retinopathy [5,6,7,8]