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Experimental studies indicate that GLP-1 signaling can enhance genioglossus muscle tone, thereby reducing susceptibility to airway collapse during sleep (38, 39)

However, scientific evidence demonstrating added weight loss benefit from combining the two is limited, and the primary mechanism driving weight loss in such a combination would still be semaglutide's GLP-1 activity

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Studies of endogenous GLP-1 release and administration of long acting GLP-1 agonists show two mechanisms of action (78)

The absolute bioavailability of Semaglutide injections is 89% (source)