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Consequently, SSB2 exhibits anti-ferroptosis and anti-neuroinflammatory effects, attenuating the activation of the LPS-induced primary microglial TLR4/NF-B signaling pathway in a GPX4-dependent manner (Wang et al., 2023c)

Of particular relevance to cancer cell therapy, LNPs surface-functionalized with antibody fragments targeting CD5 (a T-cell surface marker) and encapsulating CAR-encoding mRNA have enabled direct in vivo CAR gene modification of T cells, circumventing the need for complex ex vivo manufacturing (181)

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