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Acknowledgements The authors thank the Cloning, Cell Expression, Protein Purification and Assay Development Core Facilities of iHuman Institute for their support

Patients older than 70 years were excluded to reduce confounding by age or comorbidity-associated fatigue (80 patients)

Oxidative stress is an imbalance between oxidants and antioxidants in favor of the oxidants, leading to a disruption of redox signaling and control and/or molecular damage (Sies, 2015) that harm lipids, proteins and DNA (Schieber and Chandel, 2014)

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Jirau-Colon H, Gonzalez-Parrilla L, Martinez-Jimenez J, Adam W, Jimenez-Velez B