In the context of current cost and resource constraints, these are reasonable, clinically grounded alternatives that still acknowledge that obesity is a chronic disease
Acta 1863, 24222435
It impairs BBB permeability by inducing the degradation of tight junction proteins (e.g., occludin, claudin-5), thereby exacerbating neuroinflammation (Vezzani and Baram, 2007
However, as explained by the Alzheimers Drug Discovery Foundation in 2024, while urolithin A does have an impressive safety profile, its long-term safety has yet to be established.4 Also, while rare, some people can be allergic to pomegranates, which are rich in the polyphenols that are metabolized into urolithin A.21 This doesnt necessarily mean that those with pomegranate allergies will have a reaction to urolithin A supplements, but it could be something to keep in mind
For example: Tell your doctor about all your medicines and supplements before getting B12 shots