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Efforts to improve pulmonary delivery by reinforcing the mucus barrier have also progressed in the clinic (Table 3)

Tolerability Considerations A 2024 clinical study compared microencapsulated magnesium formulations with traditional sources, finding improved absorption and better gastrointestinal tolerability with advanced formulations (PMID: 39770988)

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This process may help promote consistent NO levels over time.1 Reduced gastrointestinal discomfort Some people report experiencing digestive issues with direct Nitric Oxide boosters, whereas L-Citrulline is generally well-tolerated