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Not surprisingly, many of these syndromic disorders/epilepsies are co-morbid with autism spectrum disorders (ASD), where oxidative stress is a major driver of early synaptic alterations and neuroinflammation (Aguiar et al., 2012

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Interestingly, the estimate rate of whole-body glycine synthesis in the 70-kg healthy human adult (8.16 g/day) is comparable to the measured rate of 10.1 g/day (Gibson et al

Supplementary information Supplementary Figures 113, Tables 110 and References Rights and permissions About this article Cite this article Boland, M.L., Laker, R.C., Mather, K

Data from typical U.S